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Treatment for biofilm-related Staphylococcus aureus prosthetic joint infection

In-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with cefazolin, vancomycin, and rifampicin, against Staphylococcus aureus was tested. Effect of savirin or ticagrelor on the expression of key biofilm-related genes in S. aureus was also studied. Finally effect of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection was studied in a mouse model. These experiments were performed to collect data to study the in-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with antibiotics, to study the effect of savirin or ticagrelor in the expression of key biofilm-related genes in S. aureus, and to study the effectiveness of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection in an animal model. The antibacterial and antibiofilm activity of human synovial fluid against Staphylococcus aureus was also studied. The data generated were stored and analysed using graphpad. One way ANOVA followed by Tukey multiple comparison test was used.

Software/equipment used to create/collect the data: GraphPad version 8.2.0

Software/equipment used to manipulate/analyse the data: GraphPad version 8.2.0
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    Data Record Details
    Data record related to this publication TREATMENT FOR BIOFILM-RELATED STAPHYLOCOCCUS AUREUS PROSTHETIC JOINT INFECTION
    Data Publication title Treatment for biofilm-related Staphylococcus aureus prosthetic joint infection
  • Description

    In-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with cefazolin, vancomycin, and rifampicin, against Staphylococcus aureus was tested. Effect of savirin or ticagrelor on the expression of key biofilm-related genes in S. aureus was also studied. Finally effect of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection was studied in a mouse model. These experiments were performed to collect data to study the in-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with antibiotics, to study the effect of savirin or ticagrelor in the expression of key biofilm-related genes in S. aureus, and to study the effectiveness of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection in an animal model. The antibacterial and antibiofilm activity of human synovial fluid against Staphylococcus aureus was also studied. The data generated were stored and analysed using graphpad. One way ANOVA followed by Tukey multiple comparison test was used.

    Software/equipment used to create/collect the data: GraphPad version 8.2.0

    Software/equipment used to manipulate/analyse the data: GraphPad version 8.2.0

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    • Descriptor
      This dataset consists of 5 GraphPad PRISM projects (.pxfx) and a zipped file containing XML versions of the data files and information.
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      Descriptor type Note
    • Data type dataset
  • Keywords
    • Staphylococcus aureus
    • prosthetic joint infection
    • arthroplasty
    • savirin
    • ticagrelor
    • mouse model
    • biofilm-related genes
  • Funding source
    • Townsville University Hospital Study, Education, and Research Trust Account (SERTA) funding
    • James Cook University internal funding
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    • Research themes
    Tropical Health, Medicine and Biosecurity
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- Data
    Data Locations

    Type Location Notes
    The Data Manager is: Damon Eisen
    College or Centre College of Medicine & Dentistry
    Access conditions Restricted: no access
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    • Data record size 6 files: 641 KB
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  • Data owners
      James Cook University
- Citation
    Citation Narayan, Pant; Rush, Catherine; Warner, Jeffrey; Eisen, Damon (2022): Treatment for biofilm-related Staphylococcus aureus prosthetic joint infection. James Cook University. https://research.jcu.edu.au/data/published/c991100067a711edacc8abe58a36f1d0